Evidence Tier: Preclinical — DSIP is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) that was first isolated from rabbit brain during slow-wave (delta) sleep. Also known as Emideltide. Under FDA review for 2026 reclassification.
Overview
DSIP was first described in 1977 by Schoenenberger and Monnier after its isolation from the cerebral venous blood of rabbits during electrically induced sleep. Despite decades of research, its precise mechanism remains incompletely understood.
Regulatory Status
FDA: Listed as Emideltide, scheduled for PCAC evaluation July 23-24, 2026.
References
- Schoenenberger GA, Monnier M. "Characterization of a delta-electroencephalogram (-sleep)-inducing peptide." Proc Natl Acad Sci USA. 1977;74(3):1282-1286.
Research Disclaimer
This article is compiled from peer-reviewed research and publicly available scientific literature. It is intended for educational and informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before making health-related decisions.